The Mixed Anhydride Method for the Polypeptides Synthesis

27th Nov 2017

Both organic carboxylic acid and inorganic acid can be used in the formation of acid anhydride. However, only a few have been widely applied, and in most cases, alkyl chloroformate is used. Ethyl chloroformate used in the past is mainly substituted b...
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Acetyl Hexapeptide -8 ( Argireline )

24th Nov 2017

The profileAcetyl Hexapeptide-8 is an oligopeptide that mimics the N end of SNAP- 25 protein and is composed of six amino acids. Clinical trials have confirmed that hexaeptide is an anti-wrinkle peptide active materials based on human skin biochemica...
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Anhydride Method for Polypeptide Synthesis

24th Nov 2017

In polypeptide synthesis, the initial consideration for using anhydride can be traced back to Theodor Curtius' early research about benzoylacetic acid synthesis in 1881. Besides the benzoylacetic acid is gained, BZ-Glyn-OH(n=2-6) is obtained in the r...
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Polypeptide Synthesis - N-carboxylic Acid Anhydride Method

24th Nov 2017

Hermann Leuchs found in 1906 that the carboxyl activation of amino acids and the acyl protection occurred in N-carboxyl anhydride (NCA) simultaneously. Therefore, in the German literature, it is also called Leuchs- anhydride. In principle, the deriva...
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Acid Azide Method for Polypeptide Synthesis

24th Nov 2017

As early in 1902, Theodor Curtius introduced acid azide to peptide chemistry, so it was one of the oldest condensation methods. In alkaline aqueous solutions, amino acid esters can be used in organic solvents besides the free amino acids and peptides...
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Symmetric Anhydride Method for Polypeptide Synthesis

24th Nov 2017

Symmetric Anhydride of Nα-alpha-acyl amino acid is an high-activity midbody for peptide bond formation. In contrast to the mixed anhydride method, it has no ambiguous regional selectivity with the reaction of the amine nucleophile. But peptide conden...
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The Basic Principles of the Formation of Peptide Bond

24th Nov 2017

The formation of a peptide bond (which produces a dipeptide) is a simple chemical process on the surface. It refers to two amino acid components that are connected through the peptide bond (amide bond) and remove the water simultaneously. Under...
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Polypeptide Cutting

24th Nov 2017

1. What is "cutting"?Cutting is a step in the production of polypeptides. Chemically, it is the separation of polypeptides from the resin, and removal of the excess temporary protective groups from the polypeptide side chain and the main chain.2.The...
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