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The Action Of Myostatin (MSTN)

Current research results confirm that the function of MSTN (myostatin protein peptides for sale) is highly conservative among different species, mainly inhibiting the proliferation of myoblast cells, and it is a negative regulator of muscle growth and development (Lee et al., 1999). Because the M ST N sequences of different species are highly conservative, their functions are also conservative. M cPherro N et al (1997A, 1997b) knocked out the MST N in mice by gene targeting technology and prevented it from functioning. It was found that the mutant mice size significantly larger than the wild type, each skeletal muscle mass is 2 ~ 3 times heavier than wild type, and the number of mutant mice skeletal muscle fiber is 86% higher than that of wild mice, showed that the increase in muscle mass may be caused by muscle cell hyperplasia and hypertrophy. Other scholars have found that the expression of MSTN (Myostatin) increased in the hind limb tissues and injured and regenerated muscle tissues caused by muscle atrophy in rats by suspension (Sakuma 2000). Surprisingly, the findings of  Yamanouehi et al show that M STN is also expressed in some of the fibroblasts impregnated with the wound, thought to be due to the inflammatory process that occurs early in the muscle regeneration, while the level of gene expression in the nascent skeletal muscle MST gene expression decreased. Conlon et al. (1999) even believed that in the maintenance of homeostasis of the body, MSTN might play a function similar to that of inhibiting muscle growth.

As a regulator of muscle growth, it has been widely recognized. Since it is a regulatory factor controlling the size of muscle organs, M cKnight(1997) commented on the topic of "guardians of organ growth". The decrease or loss of MSTN activity greatly increases the ratio of muscle to other tissues, so it has a good application prospect in animal husbandry production. First of all, the separation, purification and cloning of MSTN create conditions for improving the production performance of meat animals and provide theoretical basis for further breeding of fine beef cattle strains. In addition, the MSTN gene is also of great significance to the medical and pharmaceutical industry. Further studies on the mechanism of action of MSTN gene and its inhibitors provide references for the treatment of some atrophic muscle diseases in clinical practice.