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Summary and Clinical Application of DSIP

Delta sleep inducing peptide (DSIP)

In 1977, a sleep-inducing peptide compound was purified from the cerebrospinal fluid of a rabbit whose sleep was deprivated by Mormier and other scientists. Identified, it is a nine peptide with a molecular weight of 848.98, with amino acid sequence of Trp - Ala - Gly Gly - Asp - Ala - Ser - Gly - Glu. Its main physiological activity is to promote rabbits’ slow-wave sleep, and can enhance five waves in a rabbit's eeg specifically. Therefore, it is named Sleep-Inducing Peptide (DSIP). This nine-peptide has a very small content in the rabbit body, but has a strong activity. Intravenous injection 30 Nmol /kg can induce normal sleep in rabbits. Early studies on DSIP bioactivity mainly focused on its sleep inducing activity, and proved that DSIP can promote slow wave sleep in rabbits.

DSIP(Buy Delta sleep inducing peptide for sale here) clinically have been used to adjust the sleep disorder. It can also be used to prevent stroke, and may be used for the treatment of burns, or can be used as a good antiepileptic agent and antiarrhythmia drugs. DSIP can also be used as a model drug to study the drug delivery pathway of polypeptide drugs. Chiang and so oninvestigated in DSIP as model drug, such as pH, ion electric current and enzyme inhibitors on peptide drugs permeate skin transmission. The influence of DSIP in buffer solution pH = 4 ~ 9 is relatively stable but is easy to be broken down by enzymes in the skin. Therefore, when the pH = 4, we can use 0.2 mol/L O-Phenanthroline to inhibit enzyme activity and it can significantly increase the permeability of DSIP. It is important to note that DSIP has not been found to have obvious side effects on human respiration, metabolism and cardiovascular function as a drug.

Problems and controversy

As for the sleep-inducing activity of DSIP, it is widely believed that it can promote slow wave sleep and even heterogenous sleep. However, in 1997, there were also reports that it had no significant effect on sleep. Different results can be explained by individual differences, but at least the complexity of DS1P's sleep-inducing activity needs further research. There is no definitive answer to the specific receptor for DS1P in the brain so far. DSIP can have analgesic activity through the blood brain barrier. There is reason to think that the DSIP receptor may be the opioid receptor in the brain, although there is evidence that DSIP may act on opioid receptors in the brain, but the results of Taylor research suggest that the effect is unlikely to exist. What's more, There is also controversy over whether DS1P is an endogenous peptide in mammals, especially in humans.