At the beginning of twentieth Century, Fischer first synthesized polypeptides with specific sequences.
In 1932, Bergmann et al. used carbobenzoxy-(Cbz) to protect the alpha - amino group, and the peptide synthesis had a certain development.
In 1953, Vigneaud successfully synthesized the first polypeptide drug oxytocin (oxytocin).
In 1963, Merrifield used resin as a solid phase carrier to synthesize polypeptide sequence and set up a solid phase synthesis of polypeptide.
At the end of 60s, Merrifield invented first fully automatic peptide synthesizers, and first synthesized biological protease (124aa).
In 70s, the discovery of enkephalin and other opioid peptides in the brain resulted in a high tide of neuropeptide research.
In 1972, Lou Carpino first used FMOC to protect the amino group and quickly used it.
In 1984, Merrifield won the Nobel Prize in Chemistry for the invention of polypeptide solid phase synthesis technology.
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