Regeneration of organs and tissues is the goal that humanity dreams of.
People have never stopped similar dreams: How great it is if there is any tissue or organ that has the ability to regenerate. If the liver and kidneys are broken, then liver and kidneys are regenerated. If myocardial infarctions happen, it can regenerate some myocardial tissues. If a car accident breaks the hands and feet, then the hands and feet can also be regenerated.
How wonderful it is！
Unfortunately, not only humans, but also other mammals, have poor regenerative capacity: most tissues or organs do not have the regenerative capacity, or they have not been observed to have regenerative capacity. The human liver has a little regenerative ability. Mammals have a certain ability to regenerate at the tips of the digits. It is generally believed that other tissues or organs do not have the ability to regenerate.
This "common sense" which has been held for many years may change in the future.
The publication of an article published in the international scientific journal "Nature" on September 24th, 2015 reported that the team led by Dr. Pilar Ruiz-Lozano of the University of California, San Diego (UCSD) found that there is a protein follistatin-like 1 (Fstl1) on the outer membrane of the human heart. ). Under in vitro culture conditions, it can stimulate myocardial cell division and increase myocardial cells. In mice, it also increases the number of myocardial cells. In mouse and pig ischemic models of myocardial infarction, FSTL1 can promote myocardial regeneration and improve cardiac function.
These results are currently limited to animal models but have brought a glimmer of dawn to human's heart regeneration. However, some experts pointed out that the FSTL1 molecule has been known for some time, how to make it reach the required part of the treatment is still a problem. In addition, it may cause side effects such as fibrosis which is not clear how to overcome.