Barbituric acid was synthesized more than 100 years ago. It is found that barbituric acid and its derivatives have hypnotic effects. At the beginning of the twentieth Century, the use of hypnotic and the discussion of its mechanism of action led to a hypothesis that physical activities stimulate the blood vessels to produce "hypnotic", and it is the "hypnotic" that causes sleep. Under the guidance of this view, French psychologist Pieron first discovered in 1910 that when the cerebrospinal fluid of a sleep-deprived dog was extracted and injected into the ventricle of the normal dog, the recipient dogs dozed and fell asleep. They believe that animals have sleep-inducing hypnotic accumulated in cerebrospinal fluid during sleep deprivation.
During 1965-1980 years, Pa Pentti Hamel and other experts extracted a chemical called "sleep factor" from the cerebrospinal fluid of the goats that were deprived of sleep, then they injected the "sleep factor" into the ventricles of the goats, rabbits, and rats, they found that the extractive could make the recipient animals fall asleep. The molecular weight of this chemical is between 350-500, which is a peptide.
Japanese scientists also found a kind of sleep substance in the brainstem, that is, the "urine nucleoside". When people work, the urine nucleosides are accumulated in the lower thalamus, and after a certain degree of accumulation, people have a sleep requirement.
The amount of endogenous sleep chemicals is very small in the brain, which is estimated to be only about 1/1000000 grams per 100 grams of brain tissue. Therefore, unlike hypnotic drugs, a very small amount of endogenous sleep chemicals can induce sleep. It has been envisaged that a few milligrams of this chemical can cause thousands of people to sleep for hours to ten hours. It can be speculated that the synthetic drug of this chemical may be a very safe and effective hypnotic drug with no side effects.
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