Acetyl Hexapeptide -8 ( Argireline )
The profile
Acetyl Hexapeptide-8 is an oligopeptide that mimics the N end of SNAP- 25 protein and is composed of six amino acids. Clinical trials have confirmed that hexaeptide is an anti-wrinkle peptide active materials based on human skin biochemical mechanism and scientific and reasonable design. It has become the world's most popular cosmetic ingredient for anti-wrinkle, and it has been used in all high-end cosmetic products to resist wrinkles. Its efficacy is comparable to that of botulinum toxin of type A, but it avoids the disadvantages of high cost of injection and use of botulinum toxin.
The mechanism
Acetyl Hexapeptide-8 participates in the competition of SNAP-25 in the melting of the complex site, thus affecting the formation of the complex. If the bubbling complex is slightly unstable, vesicles cannot release the neurotransmitter effectively, thus weakening the muscle contraction and preventing the formation of wrinkles. It is different from the Anaesthesia mechanism of type A botulinum toxin, which allows the muscle to move and express naturally without any other side effects.
The clinical test
Add the cream of 0.005% Acetyl Hexapeptide -8 , and twice a day in 28 days, the depth and width of the wrinkles were significantly improved compared with the previous ones. It is especially suitable for anti-wrinkle maintenance of facial muscles in the eyes, forehead and face, and it reduces the depth of wrinkles.
The active ingredient
Name of INCI: Acetyl Hexapeptide -8
Cas No. : 616204-22-9
Polypeptide sequence: Ac-Glu-Glu- - -Arg-Arg-NH2
Molecular formula: C34H60N14O12S
Molecular weight: 889
Appearance: white powder
The storage and shelf life
Acetyl Hexapeptide -8 pure peptide, it is suggested that in 2-8 ° C, the shelf life is 24 months.
The security
The test showed no cytotoxicity, skin irritation, irritability and eye irritation of Areginine Essence.
Application of original liquid and recommended dosage
Anti-aging and anti-wrinkle products, add 0.005% of the liquid in the final stage of the production of cosmetics.
